Cerebral glucose metabolism in diabetes

K.C.C. van de Ven

Promotor: A. Heerschap and C. Tack
Copromotor: B. de Galan and M. van der Graaf
Radboud University Nijmegen
December 5 , 2012

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the insulin producing cells in the islets of Langerhans have been destroyed. Insulin is necessary for a normal glucose metabolism and is particularly important to stimulate glucose uptake when plasma glucose levels increase, e.g. after a meal. the work performed in this thesis contributes to a better understanding of cerebral glucose uptake and metabolism under hypoglycemic conditions in normal subjects and in patients with type 1 diabetes. Dynamic C-13 MR spectroscopy, although technically demanding, is a valuable technique to investigate brain glucose metabolism in humans, in vivo. Recurrent hypoglycemic incidents as experienced by patients with T1DM can induce cerebral adaptations that may protect cerebral functioning.

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