(added MAGIC group as 6th group)
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==Highlight==
 
==Highlight==
  
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'''''Philips et al.''' have published a paper in [https://link.springer.com/article/10.1007%2Fs00330-019-06277-7 European Radiology] entitled: USPIO-enhanced MRI of pelvic lymph nodes at 7-T: preliminary experience''
  
'''''Grob et al.''' have published a paper in [https://link.springer.com/article/10.1007%2Fs00330-018-5740-4 European Radiology] entitled: Imaging of pulmonary perfusion using subtraction CT angiography is feasible in clinical practice''
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The purpose of this study was to evaluate the technical feasibility of high-resolution USPIO-enhanced magnetic resonance imaging of pelvic lymph nodes (LNs) at ultrahigh magnetic field strength.
  
  
Subtraction computed tomography (SCT) is a technique that uses software-based motion correction between an unenhanced and an enhanced CT scan for obtaining the iodine distribution in the pulmonary parenchyma. This technique has been implemented in clinical practice for the evaluation of lung perfusion in CT pulmonary angiography (CTPA) in patients with suspicion of acute and chronic pulmonary embolism, with acceptable radiation dose. This paper discusses the technical principles, clinical interpretation, benefits and limitations of arterial subtraction CTPA.
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High-resolution 7-T MR gradient-echo imaging was obtained robustly in all patients without suffering from RF-related signal voids. USPIO signal decay in LNs was visualized using computed TE imaging at TE = 8 ms and an R2* map derived from water-selective imaging. Anatomically, LNs were identified on a combined reading of computed TE = 0 ms images from water-selective scans and images from lipid-selective scans. A range of 3-48 LNs without USPIO signal decay was found per patient. These LNs showed high signal intensity on computed TE = 8 and 14 ms imaging and low R2* (corresponding to high T2*) values on the R2* map.
  
  
[[File: Nov2018.JPG|600px]]
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USPIO-enhanced MRI of the pelvis at 7-T is technically feasible and offers opportunities for detecting USPIO uptake in normal-sized LNs, due to its high intrinsic signal-to-noise ratio and spatial resolution.
  
'''Key Points:''' • SCT uses motion correction and image subtraction between an unenhanced and an enhanced CT scan to obtain iodine distribution in the pulmonary parenchyma. • SCT could have an added value in detection of pulmonary embolism. • SCT requires only software implementation, making it potentially more widely available for patient care than dual-energy CT.
 
  
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[[File:highlightsept2019.jpg|600px]]
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'''Key Points:''' • USPIO-enhanced MRI at 7-T can indicate USPIO uptake in lymph nodes based on computed TE images. • Our method promises a high spatial resolution for pelvic lymph node imaging.
  
 
See more in the [[Highlight Archive]].
 
See more in the [[Highlight Archive]].

Latest revision as of 16:51, 12 September 2019

Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The six fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed), advanced x-ray tomographic imaging (AXTI), and Image-guided Interventions (MAGIC). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.

Highlight

Philips et al. have published a paper in European Radiology entitled: USPIO-enhanced MRI of pelvic lymph nodes at 7-T: preliminary experience

The purpose of this study was to evaluate the technical feasibility of high-resolution USPIO-enhanced magnetic resonance imaging of pelvic lymph nodes (LNs) at ultrahigh magnetic field strength.


High-resolution 7-T MR gradient-echo imaging was obtained robustly in all patients without suffering from RF-related signal voids. USPIO signal decay in LNs was visualized using computed TE imaging at TE = 8 ms and an R2* map derived from water-selective imaging. Anatomically, LNs were identified on a combined reading of computed TE = 0 ms images from water-selective scans and images from lipid-selective scans. A range of 3-48 LNs without USPIO signal decay was found per patient. These LNs showed high signal intensity on computed TE = 8 and 14 ms imaging and low R2* (corresponding to high T2*) values on the R2* map.


USPIO-enhanced MRI of the pelvis at 7-T is technically feasible and offers opportunities for detecting USPIO uptake in normal-sized LNs, due to its high intrinsic signal-to-noise ratio and spatial resolution.


Highlightsept2019.jpg

Key Points: • USPIO-enhanced MRI at 7-T can indicate USPIO uptake in lymph nodes based on computed TE images. • Our method promises a high spatial resolution for pelvic lymph node imaging.

See more in the Highlight Archive.

News

For older news, see the News Archive.