Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The five fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed) and advanced x-ray tomographic imaging (AXTI). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.

Highlight

Our team published on the successful reintroduction of Combidex-enhanced MRI (nano-MRI) in clinical practice in the Radboudumc. Last week the paper ‘Ultra-small superparamagnetic iron oxides for metastatic lymph node detection: back on the block’ appeared online in the journal Wiley Reviews Nanomedicine and Nanobiotechnology.

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Combidex-enhanced MRI at 3 Tesla of a 53-year-old patient with recurrent prostate cancer after radical prostatectomy and radiotherapy (PSA-level 3.9 ng/ml). Twenty-seven hours after administration of Combidex benign lymph nodes have accumulated the contrast agent, becoming black on a 3D iron-sensitive MRI scan. Metastatic lymph nodes retain signal and therefore stay white. A large (7 mm) metastatic lymph node is visible on Combidex MRI as a white spherical structure in two orthogonal planes through the node (blue circles in coronal (A) and axial images (B)). A smaller metastatic white node (2-3 mm) is indicated with red circles in the coronal (C) and axial (D) reconstructions (orthogonal planes through the node of interest) of the 3D data set. The other small spherical structures are blood vessels, best appreciated when scrolling through the 3D image data set.

See more in the Highlight Archive.

News

  • June 14, 2017: Martijn Schouten has obtained his PhD for his thesis MRI-guided prostate biopsy: which direction?
  • June 14, 2017: Martijn Hoogenboom will defend his PhD thesis at 14:30 .
  • June 14, 2017: Maarten de Rooij will defend his PhD thesis at 12:30 .
  • June 9, 2017: Sandra Heskamp has received the title of jPI (junior Principle Investigator) for the duration of 3 years (2018-2020).
  • June 9, 2017: Jurgen Fütterer has received the title of PI (Principle Investigator).
  • May 30, 2017: Clarisa Sanchez has been appointed Associate Professor.
  • May 22, 2017: Inge van der Kroon has obtained her PhD for her thesis Evaluation of radiotracers for beta cell imaging
  • May 12, 2017: Daphne Lobeek received the Young Investigators Award for best presentation ("PET/CT imaging of angiogenesis in head and neck squamous cell carcinoma patients") at the Young Investigators Day of the Dutch Task Force for Head and Neck Tumors (NWHHT).
  • April 4, 2017: At the European Congress of Radiology 2017, Vienna, Alejandro Rodríguez-Ruiz was awarded the Best Scientific Paper Presentation award within the topic Breast for his talk "One-view Digital Breast Tomosynthesis: Do we need more?"
  • March 21, 2017: Thomas van den Heuvel will present at the grande finale of Radboud Talks on the 21st of March. Tickets can be obtained here.
  • March 20, 2017: Maximilian Wiesmann, under the supervision of Arend Heerschap, succesfully defended his PhD thesis entitled "Vascular Risk Factors and alzheimers disease- Therapeutic approaches in mouse models". He was promoted cum laude.
  • March 17, 2017: Rashindra Manniesing received a grant from ERA-NET NEURON (940 kE) together with Anne Vik (Norway), David Menon (UK) and Paul Parizel (Belgium) to work on a new axonal injury classification system in neurotrauma imaging. In Nijmegen there will be one research position available to work on the development of deep learning algorithms.
  • March 17, 2017: DIAG has a new vacancy for a PhD or postdoc to work on deep learning in neurotrauma imaging.
  • March 7, 2017: The work by Midas Meijs on a new technique for visualizing vascular flow disturbances in the brain which was presented at the ECR 2017 was mentioned in Aunt Minnie .
  • March 6, 2017: Joris Bukala started as a new PhD student at DIAG.
  • March 6, 2017: Marco Caballo started working as a PhD student at the AXTI group, focusing on analysis and new applications of 3D surface and dedicated CT images of the breast.
  • March 6, 2017: Valentin Kotov started his master thesis research at the DIAG group.
  • February 16, 2017: The demonstration of the 'Multimodal Workstation for Analysis of Retinal Images' by Bart Liefers was selected as the winner of the live demonstration workshop at SPIE Medical Imaging 2017.
  • February 10, 2017: Mijke Buitinga received a grant of 323.470,- euro from an translational call from ZonMW in combination with the Diabetes fund. Other people involved are Maarten Brom Martin Gotthardt and H. Fernandes, L. Ferreira (Center for Neuoscience and Cell Biology (CNC), University of Coimbra, Portugal. Aim of the project is to determine the specificity of 111 In-exendin during the course of T2D and to examine the effect of glycemic control on the correlation between pancreatic 111 In-exendin uptake, beta-cell mass and GLP-1R expression in humans.
  • February 3, 2017: Our departments' Preclinical MRI scanners were featured on Dutch national television as part of a program on autism research. You can watch the full program here.
  • January 25, 2017: Isabell Steinseifer has obtained her PhD for her thesis Novel MR sequences for fast and robust metabolic imaging.
  • January 25, 2017: Lecture of Professor Tone Frost Bathen, Head "MR Cancer Group"at the Norwegian University of Science and Technology (Norges teknisk-naturvitenskapelige universite, NTNU). Professor Bathen is part of the committee for the PhD thesis defense of Isabell Steinseifer. Before the defense, Professor Bathen will give a lecture at our department. Our department has an active collaboration with her group, and she and her team have been using ProCad for quite some time. The title of the lecture is A brief summary of prostate cancer PET/MR research at NTNU, Trondheim, Norway. Time January 25th, Wednesday from 11.00-12.00 hr at the St. Annakamer route 766.
  • January 12, 2017: Thessa Kockelkorn has obtained her PhD for her thesis Interactive texture analysis in chest CT scans.
  • January 11, 2017: Mark Rijpkema received a research grant from KWF. Projectleaders are Mark Rijpkema, Otto Boerman, Hans de Wilt. Title of project is Fluorescence image-guided surgery in patients with peritoneal carcinomatosis of colorectal origin. Aim of the project: The primary goal of this project is to evaluate the feasibility of intraoperative fluorescence imaging in patients with peritoneal carcinomatosis of colorectal origin undergoing cytoreductive surgery. The amount he received is € 567.865 for 4 years.
  • January 10, 2017: Otto Boerman, Sandra Heskamp and Jan van Hest of the Department of Bio-organic Chemistry, Radboud University received a grant of 584.055,- euro for Bimodal PSMA ligands for intra-operative tumor detection and photodynamic therapy of prostate cancer. One of the main challenges in the management of prostate cancer is the high rate of disease recurrence after radical prostatectomy, due to incomplete resection of lymph node metastases or positive resection margins. In this KWF project, they will develop bimodal PSMA ligands which specifically target prostate cancer cells. These ligands will be labelled with a radionuclide and fluorophore which allows intra-operative radionuclide detection and near-infrared fluorescence imaging of prostate cancer lesions. Furthermore, they will explore the potential of photodynamic therapy to specifically irradiate small prostate cancer lesions.
  • January 10, 2017: Sandra Heskamp received a grant of 656.250,- euro towards personalized use of immune checkpoint inhibitors by imaging of the PD-1/PD-L1 pathway. Immune checkpoints inhibitors activate the patient’s own immune system to kill tumors cells. These agents have shown impressive and durable anti-tumor responses. Unfortunately, only a subgroup of patients benefits from immune checkpoint inhibitors. In this KWF proposal, we will develop non-invasive imaging techniques using radiolabeled high-affinity targeting molecules to monitor the expression of immune checkpoints during conventional and experimental anti-cancer therapies. Based on these results, we will design treatment combination strategies to increase the therapeutic efficacy of immune checkpoint inhibitors.

For older news, see the News Archive.