Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The five fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed) and advanced x-ray tomographic imaging (AXTI). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.

Highlight

Holland et al. have published a paper in Breast Cancer Research entitled: Influence of breast compression pressure on the performance of population-based mammography screening'

Background In mammography, breast compression is applied to reduce the thickness of the breast. While it is widely accepted that firm breast compression is needed to ensure acceptable image quality, guidelines remain vague about how much compression should be applied during mammogram acquisition. A quantitative parameter indicating the desirable amount of compression is not available. Consequently, little is known about the relationship between the amount of breast compression and breast cancer detectability. The purpose of this study is to determine the effect of breast compression pressure in mammography on breast cancer screening outcomes.

Holland-12-1-2017.png

Results Percent dense volume increased with increasing pressure, while breast volume decreased. Sensitivity in quintiles with increasing pressure was 82.0%, 77.1%, 79.8%, 71.1%, and 70.8%. Sensitivity based on interval cancers within 12 months was significantly lower in the highest pressure quintile compared to the third (84.3% vs 93.9%, p = 0.034). Specificity was lower in the lowest pressure quintile (98.0%) compared to the second, third, and fourth group (98.5%, p < 0.005). Specificity of the fifth quintile was 98.4%.

Conclusion Results suggest that if too much pressure is applied during mammography this may reduce sensitivity. In contrast, if pressure is low this may decrease specificity.


See more in the Highlight Archive.

News

  • January 15, 2018: Thijs Kooi will defend his PhD thesis Computer aided diagnosis of breast cancer in mammography using deep neural networks 16:30.
  • December 20, 2017: Babak Ehteshami Bejnordi will defend his PhD thesis on Histopathological diagnosis of breast cancer using machine learning at 10:30.
  • December 18, 2017: Kristian Overduin will defend his PhD thesis on MRI-guided interventions for fast diagnosis and focal treatment of (recurrent) prostate cancer at 16:30.
  • December 18, 2017: Jean-Paul Charbonnier will defend his PhD thesis on Segmentation and Quantification of Airways and Blood Vessels in Chest CT at 14:30.
  • December 13, 2017: Geert Litjens and Ritse Mann were featured in the Dutch news show Nieuwsuur in an item about the automatic lymph node metastasis detection system which also resulted in a JAMA paper.
  • December 12, 2017: The work by Alejandro Rodriguez-Ruiz and Ioannis Sechopoulos on the comparison of radiologists and artificial intelligence for detecting breast cancer in mammography, which was presented at the RSNA 2017, was covered in Aunt Minnie .
  • December 5, 2017: Erik Aarntzen has, in collaboration with prof.dr. Michel van den Heuvel (Respiratory Diseases) and prof.dr. Jolanda de Vries (Tumor Immunology), been awarded a 418K grant for a project aiming to demonstrate increase of tumor-infiltrating CD8+ T cells in non-small cell lung cancer during treatment with durvalumab and validate imaging results with quantitative pathological image analysis.
  • December 2, 2017: Bram van Ginneken gave an interview to the Dutch newspaper 'de Volkskrant' about AI for medical image analysis.
  • December 1, 2017: During the annual meeting of the Dutch Physiology Association, Dr. Martijn Maessen received the prestigious Hamburger Award for best Thesis 2017. To read his thesis entitled “Cardiovascular benefits of lifelong exercise” click this link. Martijn was the first PhD student co-promoted by Dr. Rik Hansen from MUSIC (Dr. H.H.G. Hansen). The other members of the promotion team were prof. M.T.E. Hopman (promotor), prof. D.H.J. Thijssen (promotor) and Dr. T.M.H. Eijsvogels (co-promotor).
  • November 30, 2017: Anton Schreuder received the RSNA Trainee Research Prize for his research project "Use of a Risk Model Combining Clinical Information and CT Findings to Customize Follow-Up Intervals in Lung Cancer Screening" in the Chest category.
  • November 27, 2017: On November 10 and 11, Leon de Jong and Anton Nikolaev performed research on the InScience festival on behalf of the MURAB project. Visitors of the festival were able to actively participate in research in the Mariënburg chapel, which was part of the festivals DIY labs. The aim is to develop and validate new methods for 3D ultrasound acquisitions. Later on, this will enable accurate image fusion of MRI and US datasets, which is required in the MURAB project. The MURAB project focusses on improving accuracy and efficiency in the diagnostic workup of breast cancer and muscle disease patients. The cooperating students; Vera Poort, Harm Weekenstroo, Pim van Lochem and Anne ten Dam are hereby thanked for their help at the festival. The setup was well visited and a total number of 22 volunteers were scanned. For researchers as well as festival visitors, this event was very informative and fun and is definitely worth repeating.
  • November 24, 2017: During the PhD retreat organized by the RIHS, Thomas van den Heuvel won the award for best oral presentation with his presentation on ‘automated detection of maternal risk factors in developing countries’, while Wouter Bulten won the awards for the best 4-slide short talk.
  • November 24, 2017: Thomas van den Heuvel wins the prize for the ‘Best Oral Presentation’ of the Radboud Institute for Health Sciences PhD retreat 2017 for his presentation entitled: ‘Automated detection of maternal risk factors in developing countries’.
  • November 23, 2017: Linda Heskamp has received a poster award for her presentation during the Neuromuscular Disease congress in Berlin about their MRI muscle work in patients with the muscle disease facioscapulohumeral dystrophy and Myotonic Dystrophy
  • November 21, 2017: The Efficient Deep Learning (EDL) program in which Henkjan Huisman and Jeroen van der Laak have two research projects and Bram van Ginneken is on the advisory board, has been awarded a NWO Perspectief grant.
  • November 16, 2017: Charlotte van der Vos has obtained her PhD.
  • November 10, 2017: Maarten Kroes has obtained his PhD for his thesis Impact of laser guidance in image-guided needle interventions
  • November 9, 2017: ing. Gert Weijers has received an NWO Open Mind grant for his research proposal together with Freke Wilmink (a Gynaecologist at Radboudumc) entitled: What do the lungs of unborn children sound like? at NWO’s innovation festival TEKNOWLOGY, 9 November 2017.
  • October 31, 2017: Sandra Heskamp has received the 2017 European Association of Nuclear Medicine (EANM) Eckert & Ziegler Abstract Award for the following abstract: Monitoring tumor PD-L1 expression with microSPECT/CT during radiotherapy Sandra Heskamp, Janneke D.M. Molkenboer-Kuenen, Gerwin W. Sandker, Peter J. Wierstra, Johan Bussink, Otto C. Boerman.The annual congress of the EANM has more than 2000 submitted abstracts and the top 5 are selected to receive the EANM Eckert & Ziegler Abstract award.
  • October 19, 2017: Arend Heerschap has been nominated as Honorary Member of the ESMRMB. This honour has only been awarded 13 times in the 34 years of the existence of the ESMRMB.
  • October 4, 2017: Katharina Holland has obtained her PhD for her thesis Breast density measurement for personalised screening.
  • September 25, 2017: Edwin ter Voert has obtained his PhD for his thesis Multimodal and multiparametric imaging in colorectal liver metastasis
  • September 24, 2017: Dr. Rik Hansen was awarded the ‘best published paper’-award by the European Federation of Societies for Ultrasound in Medicine and Biology for the Stroke publication entitled ‘Validation of noninvasive in vivo compound ultrasound strain imaging using histologic plaque vulnerability features’. September 24, 2017: At the 29th Euroson congress, 2017 Ljubljana (Slovenia).
  • September 13, 2017: Marco Caballo got the first place in the poster competition organized at the Summer school "Advanced methods in biomedical image analysis" (Brno, Czech Republic) with his work entitled "An automatic segmentation algorithm for tissue classification of dedicated breast CT images".
  • August 31, 2017: Geert Litjens has been awarded a VENI grant to work on a deep learning-based automated tissue analysis method for better prostate cancer prognosis assessment.
  • August 25, 2017: Midas Meijs' work on a new color-mapping technique in 4D-CT, which he presented at ECR, has been nominated in the category Scientific Paper of the year by Aunt Minnie.
  • July 6, 2017: Maarten de Rooij has obtained his PhD for his thesis Multiparametric MRI in prostate cancer

For older news, see the News Archive.