Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The five fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed) and advanced x-ray tomographic imaging (AXTI). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.


Holland et al. have published a paper in Breast Cancer Research entitled: Influence of breast compression pressure on the performance of population-based mammography screening'

Background In mammography, breast compression is applied to reduce the thickness of the breast. While it is widely accepted that firm breast compression is needed to ensure acceptable image quality, guidelines remain vague about how much compression should be applied during mammogram acquisition. A quantitative parameter indicating the desirable amount of compression is not available. Consequently, little is known about the relationship between the amount of breast compression and breast cancer detectability. The purpose of this study is to determine the effect of breast compression pressure in mammography on breast cancer screening outcomes.


Results Percent dense volume increased with increasing pressure, while breast volume decreased. Sensitivity in quintiles with increasing pressure was 82.0%, 77.1%, 79.8%, 71.1%, and 70.8%. Sensitivity based on interval cancers within 12 months was significantly lower in the highest pressure quintile compared to the third (84.3% vs 93.9%, p = 0.034). Specificity was lower in the lowest pressure quintile (98.0%) compared to the second, third, and fourth group (98.5%, p < 0.005). Specificity of the fifth quintile was 98.4%.

Conclusion Results suggest that if too much pressure is applied during mammography this may reduce sensitivity. In contrast, if pressure is low this may decrease specificity.

See more in the Highlight Archive.


  • December 7, 2018: Marlene Hekman will defend her PhD thesis on Tumor-targeted imaging of cancer with radiolabeled and fluorescently labeled antibodies. Towards clinical implementation at 10.30.
  • December 7, 2018: Jan Jurre Mordang will defend his PhD thesis with the title Towards an independent observer of screening mammograms:detection of calcifications at 12.30.
  • October 4, 2018: Peter Laverman, Frank Nijssen and Sandra Heskamp are participating in the project “Advancing Nuclear Medicine – Petten Fieldlab”. In this project we will set up a new fieldlab for the development and market introduction of innovative types of radionuclide therapy. This project is a collaboration between NRG, Radboudumc, NKI-AVL, ErasmusMC, VUMC, FutureChemistry, and NucMed BV. Our group will evaluate the therapeutic efficacy of novel PSMA-targeting ligands radiolabeled with the alpha-emitting radionuclide lead-212 for prostate cancer treatment.
  • September 27, 2018: Suzan Vreemann has succesfully defended her thesis 'Breast MRI; evaluation of clinical practice and future perspectives' and obtained her PhD.
  • September 3, 2018: Michelle Foko joined the AXTI group for her BSc internship. She is involved in the optimization of softwares for simulation of breast compression using 3D surface scan camera under the supervision of Christian Fedon.
  • September 3, 2018: Valentin Koch joined the AXTI group for his MSc internship. He will work with Marco Caballo in the project "Image analysis of high-resolution CT cochlea images"
  • August 10, 2018: Christian Fedon has been awarded a travel grant to start a research collaboration with The Catholic University of South Korea. The topic is "Characterization of the breast in the Asian population for dosimetric modeling"
  • July 2, 2018: Mark Rijpkema, has been appointed as Associate Professor of Translational Multimodal Imaging as of July 1th. Mark will work in the field of molecular imaging, with a special focus on intraoperative imaging and image-based surgery using fluorescence imaging.
  • June 28, 2018: Evita Wiegers has obtained her PhD.
  • June 19, 2018: EU ITN has approved the ISPIRE-MED project for 265 kEuro to BIOMR
  • June 12, 2018: Kaman Chung has obtained her PhD for her thesis Malignancy estimation of subsolid nodules.
  • May 31, 2018: Last weekend, Anton Schreuder was presented the ESTI Magna Cum Laude Award for best abstract presentation at the ESTI-ESCR 2018 conference in Geneva. The winning abstract was titled "What is a perifissural nodule? Low inter-observer agreement in NLST data".

For older news, see the News Archive.