Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The five fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed) and advanced x-ray tomographic imaging (AXTI). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.


Grob et al. have published a paper in European Radiology entitled: Imaging of pulmonary perfusion using subtraction CT angiography is feasible in clinical practice

Subtraction computed tomography (SCT) is a technique that uses software-based motion correction between an unenhanced and an enhanced CT scan for obtaining the iodine distribution in the pulmonary parenchyma. This technique has been implemented in clinical practice for the evaluation of lung perfusion in CT pulmonary angiography (CTPA) in patients with suspicion of acute and chronic pulmonary embolism, with acceptable radiation dose. This paper discusses the technical principles, clinical interpretation, benefits and limitations of arterial subtraction CTPA.


Key Points: • SCT uses motion correction and image subtraction between an unenhanced and an enhanced CT scan to obtain iodine distribution in the pulmonary parenchyma. • SCT could have an added value in detection of pulmonary embolism. • SCT requires only software implementation, making it potentially more widely available for patient care than dual-energy CT.

See more in the Highlight Archive.


  • February 26, 2019: Rick Philipsen will defend his PhD thesis with the title 'Automated chest radiography reading: improvements, validation, and cost-effectiveness analysis' at 16.30 in the Aula of the Radboud University.
  • December 20, 2018: Kaj Gijsbertse has obtained his PhD.
  • December 11, 2018: Jan Jurre Mordang has succesfully defended his PhD thesis with the title ' Towards an independent observer of screening mammograms: detection of calcifications'.
  • December 11, 2018: Wulphert Venderink has obtained his PhD.
  • December 7, 2018: Marlene Hekman has obtained her PhD.
  • December 5, 2018: The work by Marco Caballo and Ioannis Sechopoulos about using machine learning to generate super-resolution digital breast phantoms for accurate simulations of new imaging systems, published in Physics in Medicine and Biology, was covered in Physics World and in Aunt Minnie
  • November 27, 2018: Francesco Ciompi and Jeroen van der Laak have been awarded an ICT12 Horizon 2020 grant as part of a consortium of European partners. The goal of this 4-year project, EXA MODE, is to build tools based on artificial intelligence to aid pathologists in routine diagnostics via automatic analysis of digital pathology whole-slide images of cancer specimens across multiple organs.
  • November 23, 2018: Dagmar Grob was awarded for the best 4-slide short talk at the PhD retreat of Radboud Institute for Health Sciences (22 - 23 November 2018)
  • November 5, 2018: Marta Pinto started working as a PhD student at the AXTI group, focusing on image processing algorithms for image quality improvement in digital breast tomosynthesis.
  • October 4, 2018: Peter Laverman, Frank Nijssen and Sandra Heskamp are participating in the project “Advancing Nuclear Medicine – Petten Fieldlab”. In this project we will set up a new fieldlab for the development and market introduction of innovative types of radionuclide therapy. This project is a collaboration between NRG, Radboudumc, NKI-AVL, ErasmusMC, VUMC, FutureChemistry, and NucMed BV. Our group will evaluate the therapeutic efficacy of novel PSMA-targeting ligands radiolabeled with the alpha-emitting radionuclide lead-212 for prostate cancer treatment.
  • September 27, 2018: Suzan Vreemann has succesfully defended her PhD thesis 'Breast MRI; evaluation of clinical practice and future perspectives' .
  • September 3, 2018: Michelle Foko joined the AXTI group for her BSc internship. She is involved in the work of Christian Fedon in optimization of a software for simulation of breast compression using 3D surface scan camera.
  • September 3, 2018: Valentin Koch joined the AXTI group for his MSc internship. He will work with Marco Caballo in the project "Image analysis of high-resolution CT cochlea images"
  • August 10, 2018: Christian Fedon has been awarded a travel grant to start a research collaboration with The Catholic University of South Korea. The topic is "Characterization of the breast in the Asian population for dosimetric modeling"

For older news, see the News Archive.