Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The six fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed), advanced x-ray tomographic imaging (AXTI), and Image-guided Interventions (MAGIC). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.


Grob et al. have published a paper in European Radiology entitled: Imaging of pulmonary perfusion using subtraction CT angiography is feasible in clinical practice

Subtraction computed tomography (SCT) is a technique that uses software-based motion correction between an unenhanced and an enhanced CT scan for obtaining the iodine distribution in the pulmonary parenchyma. This technique has been implemented in clinical practice for the evaluation of lung perfusion in CT pulmonary angiography (CTPA) in patients with suspicion of acute and chronic pulmonary embolism, with acceptable radiation dose. This paper discusses the technical principles, clinical interpretation, benefits and limitations of arterial subtraction CTPA.


Key Points: • SCT uses motion correction and image subtraction between an unenhanced and an enhanced CT scan to obtain iodine distribution in the pulmonary parenchyma. • SCT could have an added value in detection of pulmonary embolism. • SCT requires only software implementation, making it potentially more widely available for patient care than dual-energy CT.

See more in the Highlight Archive.


  • August 23, 2019: Mehmet Dalmis will defend his PhD thesis with the title' Automated Analysis of Breast MRI: from Traditional Methods into Deep Learning' at 12.30.
  • August 23, 2019: Jan van Zelst will defend his PhD thesis with the title 'Automated 3D Breast Ultrasound. Advances in breast cancer detection, diagnosis and screening' at 14.30.
  • August 20, 2019: Anne Saris will defend her PhD thesis with the title 'Blood velocity vector imaging in the carotid artery using ultrasound' at 14.30.
  • July 2, 2019: Stein Fekkes will defend his PhD thesis with the title '3D Carotid Elastography'at 14.30.
  • May 21, 2019: Linda Heskamp received the 1st price in the Musculoskeletal MR Study Group Award for 2 presentations during the ISMRM 27th Annual Meeting 11-16 May in Montreal
  • May 1, 2019: Olga Sliwicka started working as a PhD student at the AXTI group, focusing on cardiac perfusion imaging in acute chest pain.
  • April 23, 2019: Linda Heskamp received a Rubicon Grant from the Dutch Organisation for Scientific Research (NWO)
  • April 19, 2019: Tom H. Peeters et.al. have published a paper in Imaging Hyperpolarized Pyruvate and Lactate after Blood−Brain Barrier Disruption with Focused Ultrasound
  • March 28, 2019: Leticia Gallardo Estrella has succesfully defended her PhD thesis, titled ''Quantification of COPD biomarkers in thoracic CT scans".
  • March 26, 2019: Alejandro Rodriguez-Ruiz has succesfully defended his PhD thesis titled "Artificial intelligence & tomosynthesis for breast cancer detection".
  • March 18, 2019: Domenico Pangallo joined the AXTI group for his MSc thesis about quantitative image analysis of breast cancer in dedicated breast CT imaging, under the supervision of Marco Caballo.
  • March 10, 2019: Twan Cuijpers joined the AXTI group for his MSc internship. He will work with Joana Boita in a project from LRCB (Dutch Expert Centre for Screening) that intends to create a visualization tool for teaching in mammography.
  • February 26, 2019: Rick Philipsen has succesfully defended his PhD thesis, titled 'Automated chest radiography reading: improvements, validation, and cost-effectiveness analysis'.
  • January 30, 2019: Thomas van den Heuvel defended his thesis on Automated low-cost ultrasound. He showed that a deep learning system can perform real-time detection of risk factors for pregnant women using the input from a low-cost ultrasound device. His work was covered by NOS op 3, national radio, Algemeen Dagblad, Medisch Contact, and RTL Z. Next month, Thomas will return to Ethiopia for further testing of his device.
  • January 24, 2019: Ioannis Sechopoulos was named Fellow of the American Association of Physicists in Medicine ( AAPM) due to his distinguished contributions to medical physics and the esteem in which he is held by his peers
  • January 18, 2019: Roel Verhoeven won the 'Best clinical poster award' at the Imaging the Biomechanics of Life (TOPIM) conference in Les Houches, France as hosted by the European Society for Molecular Imaging. Apart from a great sweater as a rememberance to this award, he more importantly got the opportunity to again present his work as an oral presentation for the main audience!
  • December 20, 2018: Kaj Gijsbertse has succesfully defended his PhD thesis entitled: Functional ultrasound imaging of the lower extremity
  • December 11, 2018: Jan Jurre Mordang has succesfully defended his PhD thesis with the title ' Towards an independent observer of screening mammograms: detection of calcifications'.
  • December 11, 2018: Wulphert Venderink has obtained his PhD.
  • December 7, 2018: Marlene Hekman has obtained her PhD.
  • December 5, 2018: The work by Marco Caballo and Ioannis Sechopoulos about using machine learning to generate super-resolution digital breast phantoms for accurate simulations of new imaging systems, published in Physics in Medicine and Biology, was covered in Physics World and in Aunt Minnie

For older news, see the News Archive.