Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.
Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.
The six fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed), advanced x-ray tomographic imaging (AXTI), and Image-guided Interventions (MAGIC). Clinical research is mainly focused on prostate, breast, chest and vascular disease.
Philips et al. have published a paper in European Radiology entitled: USPIO-enhanced MRI of pelvic lymph nodes at 7-T: preliminary experience
The purpose of this study was to evaluate the technical feasibility of high-resolution USPIO-enhanced magnetic resonance imaging of pelvic lymph nodes (LNs) at ultrahigh magnetic field strength.
High-resolution 7-T MR gradient-echo imaging was obtained robustly in all patients without suffering from RF-related signal voids. USPIO signal decay in LNs was visualized using computed TE imaging at TE = 8 ms and an R2* map derived from water-selective imaging. Anatomically, LNs were identified on a combined reading of computed TE = 0 ms images from water-selective scans and images from lipid-selective scans. A range of 3-48 LNs without USPIO signal decay was found per patient. These LNs showed high signal intensity on computed TE = 8 and 14 ms imaging and low R2* (corresponding to high T2*) values on the R2* map.
USPIO-enhanced MRI of the pelvis at 7-T is technically feasible and offers opportunities for detecting USPIO uptake in normal-sized LNs, due to its high intrinsic signal-to-noise ratio and spatial resolution.
Key Points: • USPIO-enhanced MRI at 7-T can indicate USPIO uptake in lymph nodes based on computed TE images. • Our method promises a high spatial resolution for pelvic lymph node imaging.
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